WHAT WE DO
Diffusion Whole Body requires the use of a latest-generation magnetic resonance scanner. In a short time it produces thousands of detailed images of organs and tissues for identifying cancer lesions of just a few millimeters; a dimension in which they are still at an early stage and thus treatable in a less invasive ways and with a high margin of success. More advanced than traditional magnetic resonance scans, DWB is the result of years of research and study that allows us to reach an early diagnosis, that in some cases could be a life-saving.
A DWB examination is like other, standard radiological investigation, but no specific preparation is needed; one does not take medication, do an enema or fast.
After the standard administrative work at reception, a radiographer will guide you to a preparation area near MRI scanner, where our specialist radiologist will assess the feasibility and safety of DWB examination for you on the basis of an in-depth interview regarding your medical history and discussion of the DWB examination process. On the doctor’s approval, you will then proceed to the MR scanner.
After you have changed into a hospital gown, the radiographer will help you get into position on the MRI bed and start the examination. While performing the DWB examination, the radiographer remains in continuous audio and visual contact. DWB examination is painless, and you can listen to music while the scans are performed.
After about 30 minutes, when all the images have been acquired the specialist radiologist will assess the image quality and authorise the end of the examination. You will then leave MRI room, and change back into your regular clothes. After a final discussion with the specialist radiologist you will have completed the examination. Once the examination is finished, you can return to your usual activities with no limitations. All the examinations will be reviewed by one of IEO’s radiologists.
A study published in the Annals of Oncology estimates that in 2014, 250 000 cancer deaths will be avoided in Europe thanks to prevention efforts such as breast and colon cancer screening. The reason why is well known: the smaller the cancer, the bigger the chances of recovery and the smaller the collateral effects of therapy.
Writing in L’Espresso in 2014, Prof. Umberto Veronesi identified two routes to early diagnosis: molecular imaging, that allow to detect cancer marker in blood and the evolution of magnetic resonance.
He promoted the research on Diffusion Whole Body at IEO, as the type of magnetic resonance study best suited to detecting cancer at an early stage.
dati da “I numeri del cancro in Italia 2016” a cura di AIOM e AIRTUM
For an MRI examination, the patient is placed in a large magnet. Then, using radiofrequency magnetic field pulses at the appropriate “resonant” frequency, hydrogen atoms are tipped out of their equilibrium. The MRI scanner detects the signal induced by the hydrogen atoms (mainly from water and fat) during their return to equilibrium.
A computer then transforms this signal to produce anatomical and functional images of the human body. All this takes place without exposing the patient to ionizing radiation. MRI has been used routinely to produce detailed anatomical images of patients for more than 30 years. For about 25 years, it has been possible to use MRI to study the microscopic diffusion of water molecules in the human body (diffusion weighted MRI technique) as a means for obtaining clinically useful information [1]. The first clinical application of diffusion weighted MRI was in the detection of stroke in the brain, but in the last 10 years diffusion weighted MRI has seen growing use in cancer imaging throughout the body [2].
Thanks to technological developments in the last few years, it is now possible to capture images of the whole body with the diffusion weighted MRI technique in a short time, giving rise to the Diffusion Whole Body (DWB) examination [3].
The execution of DWB examinations, and the interpretation of the resulting images have been standardised by the leading research centres [4] and the technique has progressively become available for cancer patients [5]. Recent scientific publications report a diagnostic accuracy of DWB comparable to that of other and older whole body imaging techniques that use radiation and contrast agents, such as Positron Emission Tomography (PET) and Computed Tomography (CT) [6,7].